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Common Side Effects and How to Manage Them Potential side effects include: Nausea Constipation Abdominal pain Hypoglycemia (low blood sugar) Gastrointestinal discomfort Mitigate these side effects by: Hydrating adequately Gradually increasing dosage Taking medication consistently at the same time each week Regularly communicating with your healthcare provider Combining Semaglutide with Lifestyle Changes Semaglutide is most effective when combined with: Balanced Nutrition: Prioritize whole foods, lean proteins, vegetables, and fiber-rich grains

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found that cardiac microvascular endothelial cells isolated from T2DM mice exhibited increased expression of pro-ferroptotic genes (Tfrc, Acsl4, Ptgs2), decreased expression of anti-ferroptotic genes (Gpx4, Slc7a11), and elevated lipid peroxidation (MDA, 4-HNE), indicating that hyperglycemia also induces ferroptosis in endothelial cells [97]